Grant applications Clinical Genomics/Genome Center:

Name project:                         Using mDNA in prediction of radiation-induced toxicity in patients that undergo radiotherapy
period::                                    2012-2014
Project coordinator:                 Prof.dr. Ph. Lambin/Prof.dr. H.J.M. Smeets
Other participants:                   A. Voets
Funded by:                              NGI
Applicant address:                   GROW-UM
sum of contract in euro's:          € 124.750,-

Name project:                         Ontrafeling van de genetische oorzaken bij sporadische mitochondriële aandoeningen
period::                                    2012-2014
Project coordinator:                 Prof.dr. H.J.M. Smeets
Other participants:                   S. Sallevelt
Funded by:                              Metakids
Applicant address:                   CARIM-UM
sum of contract in euro's:          € 50..000,-

Name project:                         The integration of mitochondrial DNA diagnostics in radiotherapy decision support systems for personalized medicien: a theranostics approach.
period:                                    2012-2014
Project coordinator:                 Prof.dr. H.J.M. Smeets            
Funded by:                              Academisch Fonds, KLG 15 Beeld-lab, azM
sum of contract in euro's:          € 93.500,- (materieel)

 Name project:                         Cell line models genetic cardiomyopathy
period::                                    2012-2016
Project coordinator:                 Prof.dr. H.J.M. Smeets
Other participants:                   R. Lutgens
Funded by:                              azM-incentive
Applicant address:                   CARIM-UM
sum of contract in euro's:          € 179.000,-

 Name project:                         Unraveling the genetic and pathophysiological basis of mitochondrial myopthies
period::                                    2012-2016
Project coordinator:                 Prof.dr. H.J.M. Smeets
Other participants:                   T. Theunissen
Funded by:                              Diabetesfonds
Applicant address:                   GROW-UM
sum of contract in euro's:          € 249.693,-

Name project:                        
 High-hroughput and comprehensive resequencing of cardiomyopathy genes by
                                                CHIP based DNA-sequencing technology (CardioCHIP) –
Dossiernummer 94527019
                     
Period:                                     november 2010- mei 2011                          
Project coordinator:  
                Prof.dr. H.J.M. Smeets
School:                                     CARIM
Funded by:                               ZonMw
Sum of contract in Euro’s:         €  25.000,-

Name project:                          Alma-in-Silico                     
Period:                                     2008-2011 
School:   
                                  GROW/CARIM                          
Project coordinator:  
                Prof.dr. A. Renard (Liège) 
Other participants:                    Dr. K. Hoffmann (Aachen), Dr. J.P. Noben (Hasselt), Dr. H.J.M. Smeets (Maastricht) 
Applicant address:                    Université de Liège,GIGA, 7  Liège 
Funded by:                               EU-INTERREG
Sum of contract in Euro’s:         € 7.659.055,00 in total
                                                € 1.622.500 Maastricht

Name project:                         New tools for the identification of nutrional modulators of mitochondrial
                                               activity: small molecules that promote health and disease |
Period:                                    2006-2010    
School:  
                                  CARIM
Project coordinator:                 Prof.Dr. J.M.A. Smeitink 
Other participants:                   Prof. Dr. B. Wieringa (RUNMC), Prof. Dr. M. Huynen (RUNMC),
                                               Dr.P.Willems (RUNMC), Prof. Dr. I. Braakman (UU), Dr. H. Smeets, Drs. A. Voets
Funded by:                              IOP-Genomics
Sum of contract in Euro’s:        € 1.979.000,-

Name project:                        Elucidation of predictive, pathological changes in OXPHOS genes, gene
                                              expression and activity in type 2 diabetes 
Period:                                   2005-2009 
School:     
                              NUTRIM
Project coordinator:                Dr. H.J.M. Smeets 
Other participants:                  Drs. F. van Tienen, Dr. I. de Coo (EMCR), Dr. K..Schoonderwoerd (
EMCR),
                                      
        Dr.W. Sluiter (EMCR)
Funded by:                             Diabetesfonds
Sum of contract in Euro’s:       € 202.124,- 

Name project:                      Création d’un Laboratoire Virtuel de services pour la collaboration des
                                            centres de recherche et des PMEs des sciences de la vie dans l’Eurégio
                                            Meuse-Rhin  (Alma-Grid) www.alma-grid.eu  
Period:                                 2005-2007    
School:  
                               GROW
Project coordinator:              Prof.dr. A. Renard (Luik) 
Other participants:                Dr. K. Hoffmann (Aachen), Prof.J.vandenBussche (Diepenbeek), H.J.M. Smeets
                                            (Maastricht) 
Applicant address:                Université de Liège,GIGA, 7  Liège 
Funded by:                           EU-INTERREG
Sum of contract in Euro’s:     € 2.293.850,- 

Name  project:                                TUL-AIO
Period:                                 2005-2008                                  
Project coordinator:             T.A.
Ayoubi
Other participants:                R. Martherus, H.J.M. Smeets
Applicant address:                CARIM-UM, Maastricht 
Funded by:                           TUL
Sum of contract in Euro’s:     € 200.000,-

Name  project:                                 MITOCIRCLE: Mitochondrial diseases: From bedside  to genome to bedside. 
Period:                                 2004-2008                                  
Project coordinator:              H.J.M. Smeets
Other participants:                Dr. V.Tiranti (Milano), Dr.P.F.Chinnery (Newcastle), Dr. L. van den Heuvel
                                            (Nijmegen), prof.dr. A. Munnich (Paris) 
Applicant address:                GROW-UM, Maastricht 
Funded by:                           EU (FP6) 
Sum of contract in Euro’s:     € 1.967.000,


Name project:                     Microarraytechnologie in de gezondheidszorg
Period:                                2003-2006                 
Project coordinator:             Dr. H.J.M. Smeets
Funded by:                          azM-zorgvernieuwing
Sum of contract in Euro’s:    € 210.000,-

Name project:                     Determination of pathogenic gene expression profiles in tissues of patients with defects in oxidative phosphorylation, using DNA-array technology 
Period:                                2002-2006 
Project coordinator:             Dr. H.J.M. Smeets
Other participants:                Dr. I. de Coo, Prof.dr. H. Scholte, Drs. R. van Eijsden
Applicant address:               GROW-UM   
Funded by:                          Prinses Beatrix Fonds  
Sum of contract in Euro’s:    € 136.000,-

Name project:                   Characterisation of mutations that cause Alport syndrome 
Period:                              1991-1995
Project coordinator:           Dr. H.J.M. Smeets
Funded by:                        NierStichting Nederland

Name project:                  The role of mutations in type IV collagen genes in the pathogenesis of
                                        Alport yndrome and familial benign hematuria
Period:                             1995-1998
Project coordinator:          Dr. H.J.M. Smeets
Funded by:                       NierStichting Nederland

Name project:                   Molecular genetic and functional investigations of the
                                         pathogenesis of Alport syndrome and benign familial
                                         hematuria
Period:                              1998-2000
Project coordinator:           Dr. H.J.M. Smeets
Funded by:                        NierStichting Nederland

Name project:                    Genetic analysis by means of GeneChip technology
Period:                               1998-2002                                
Project coordinator:            Dr. H.J.M. Smeets

Other participants:              Prof.dr. J. Geraedts, Prof.dr. T. de Bruin, Prof.dr. W. Saris,
                                          Prof.dr. F. Ramaekers, Dr. H. Meijer, Dr.J.Geelen, Dr.
                                          C. Schrander, Dr. C. Reutelingsperger, Dr. A. Hopman.
Funded by:                         ZONMW/NWO
Sum of contract in Euro’s:   € 135.000,-

Name project:                     Elucidation of genetic pathways in the hypertrophic and
                                           failing heart by microarray technology

Period:                               1999-2003
Project coordinator:            Dr. H.J.M. Smeets, Dr. P.A. Doevendans
Other participants:               Dr. I. de Coo (EUR), Prof.dr. H.R.  Prof.dr. H. Wellens EUR),
                                           Dr. J. van Dantzig (UM), Dr. C. Marcelis (UM), Prof.dr. G.
                                           van der Vusse (UM), Dr. G. van Eys (UM), Dr. F. van der
                                           Loop (UM), Drs. B. van den Bosch (UM), Drs. W. Loots
                                           UM), Drs. J. Mulkens (UM), J. Ross (EUR).
Funded by:                          Nederlandse Hartstichting                
Sum of contract in Euro’s:    € 212.000,-

Name project:                     Development of Preimplantation Genetic Diagnosis for Triplet Repeat
                                           Diseases 
Period:                                1999-2004                 
Project coordinator:            
Dr. H.J.M. Smeets
Other participants:               Prof.dr. J. Geraedts, prof.dr. J. Evers, Dr. J. Dumoulin, Dr. C. de Die, J. Dreesen,
                                           Drs.W. Loots
Applicant address:               GROW-UM, Maastricht
Funded by:                          ZON/NWO 
Sum of contract in Euro’s:    € 307.000,-




 


 




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Grant applications Population Genetics:


Name project:                  
Opsporen van genen voor obesitas  
Period:                              2003-2005
Project coordinator:           Prof.dr.R.F.M.Vlietinck
Funded by:                        Institute Nutrim


Name project:                  
De invloed van kandidaat genen en perinatale omgeving op de bloeddruk,
                                         vet en koolhydraten metabolisme van volwassenen
 

Period:                               2003-2006
Project coordinator:           Prof.dr.R.F.M.Vlietinck
Funded by:                        FWO


Name project:                  
The influence of candidate genes and perinatal-environment on
                                         lipid and carbohydrate metabolism
 

Period:                               2004-2008
Project coordinator:           Prof.dr.R.F.M.Vlietinck/Prof.dr.J.P.M.Geraedts
Funded by:                        Diabetes Fonds Nederland