In the years starting at the end of 1995 Smeets has
established several lines of investigation within the Division of Genetics
(listed below). He started with a single research technician and heads now
a group of 14 people, performing research predominantly within CARIM and
GROW. As a consequence of becoming head of the GenomeCenter Maastricht,
research will be broadened to other research Institutes and genomics will
be added to the originally molecular genetic investigations. To keep a
clear focus in the research lines, small groups of investigators will be
headed by single staff members and will work on single themes. Smeets will
supervise these groups and will remain involved in detail in part of the
projects. As each of these groups has the obligation to grow, it can be
expected that the number of people involved will continue to expand.
PhD student, Department of Human Genetics
Title thesis: A molecular genetic approach to
myotonic dystrophy (29-11-1991).
Promotores: Prof. Dr. H. Ropers; Prof. Dr. B. Wieringa
1990-now The role of type IV
collagen mutations in the pathogenesis of Alport syndrome and familial
benign hematuria (1990-now).
Neuromuscular disorder (GROW/CARIM)
H.H. Lemmink (Nijmegen) Thesis
diagnosis and prevention of renal failure due to Alport syndrome. (Participant for The Netherlands; Concerted Action EEC 1993-1996).
genetic and functional investigations of the pathogenesis of Alport
syndrome and benign familial hematuria (1995-now).
Identification and characterisation of mitochondrial DNA mutations
in mitochondrial (cardio)myopathies (1993-now).
genetic analysis of nuclear genes in mitochondrial disease (1995-now).
I.F.M. de Coo (Nijmegen) Thesis 2001.
of preimplantation diagnostics for neuromuscular disorders (1996-now).
L.Jacobs (Maastricht) Thesis 2005.
of pathogenic gene expression profiles in tissues of patients with defects
in oxidative phosphorylation, using DNA-array technology.
van Eijsden (Maastricht) Thesis 2006.
Start project MITOCIRCLE:
“Mitochondrial diseases: From bedside to genome to bedside”, 6th
Framework Programme EU.
Coordinator for Milano, Newcastle, Nijmegen, Paris and Maastricht.
Cardiovascular disease (CARIM):
Identification of genes and genetic defects in cardiomyopathies and
Genotype-phenotype relations in LongQT syndrome and Familial Hypertrophic
R. Jongbloed (Maastricht) Thesis 2003; A. Paulussen (Maastricht) Thesis
of genetic pathways in the hypertrophic and failing heart by micro-array
B. van den
Bosch (Maastricht) Thesis 2005.
of Bioinformatic tools for large-scale gene expression analysis.
Eijssen (Maastricht) Thesis 2005.
(2004) together with the
of the Ulg
LUC (Diepenbeek) in
order to create a network that coordinates the strategic development of
the "genome pool" in the region by supporting private and